Omar M. Aly, PhD

Welcome to the home page of the Drug Design & Development Group at the Faculty of Pharmacy, Port Said University, Egypt. Our research group focus is on the design and discovery of selective anticancer agents, namely, vascular disrupting agents (VDAs) that work by acting near the colchicine binding site of the β subunit of endothelial cell tubulin, resulting in depolymerization of microtubules and disorganization of actin and tubulin. Endothelial cells of the tumor vasculature underwent apoptosis resulting in blood flow shutdown and massive tumor necrosis.